Author

William A. Sharpless

Lawrence Berkeley National Laboratory

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Genomics· 1 Synthetic Biology· 1 Systems Biology· 1

Signature Assays, Organisms & Methods

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Organism:bacteria (other)· 2 Approach:experimental assay· 2 Assay:metagenomics· 1 Assay:proteomics· 1 Approach:statistical model· 1

Frequent Co-Authors

Adam M. DeutschbaueriD· 2 shared Adam P. ArkiniD· 2 shared Kyle B. SanderiD· 2 shared Alexandria E. Velasquez· 1 shared Allison N. PearsoniD· 1 shared Anthony J. AbeliD· 1 shared Christopher J. PetzoldiD· 1 shared Douglas S. ClarkiD· 1 shared

Activity by Year

2019-2023 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 22 mutual co-author links

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2 shared papersGenomics

Adam M. DeutschbauerORCID

Mutual co-authors in cluster

Author profile →

3 papers

Recent·Most cited

Eliminating Genes for a Two Component System Increases PHB Productivity in Cupriavidus basilensis 4G11 Under PHB Suppressing, Non-Stress Conditions

Kyle B. Sander, Anthony J. Abel, Skyler Friedline, William A. Sharpless, Jeffrey M. Skerker, Adam M. Deutschbauer, Douglas S. Clark, Adam P. Arkin

This study identifies two genes in a two-component system whose deletion increases PHB productivity in Cupriavidus basilensis under non-stress conditions.

Biotechnology and Bioengineering · Aug 28, 2023Peer-reviewedGenomics

Towards Environmental Control of Microbiomes

William A. Sharpless, Kyle B. Sander, Fangchao Song, Jennifer V. Kuehl, Adam P. Arkin

This paper extends an ecological model to predict microbiome dynamics under environmental changes and shows how precise environmental perturbations can improve microbiome control.

bioRxiv · Nov 4, 2022 · PreprintSystems Biology

Host engineering for improved valerolactam production in Pseudomonas putida

Mitchell G. Thompson, Luis E. Valencia, Jacquelyn M. Blake-Hedges, Pablo Cruz‐Morales, Alexandria E. Velasquez, Allison N. Pearson, Lauren N. Sermeno, William A. Sharpless, Veronica Teixeira Benites, Yan Chen, Edward E. K. Baidoo, Christopher J. Petzold, Adam M. Deutschbauer, Jay D. Keasling

This study identifies and disrupts genes in Pseudomonas putida that cause unwanted metabolism of valerolactam, increasing its production titer.

bioRxiv · Jun 6, 2019 · PreprintSynthetic Biology