Author

Luis E. Valencia

Lawrence Berkeley National Laboratory

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Synthetic Biology· 5 Bioinformatics· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 6 Organism:bacteria (other)· 2 Research Focus:benchmarking· 1 Organism:C. elegans· 1 Assay:protein structure· 1 Assay:proteomics· 1 Research Focus:software / tool· 1

Frequent Co-Authors

Jay D. KeaslingiD· 6 shared Allison N. PearsoniD· 5 shared Edward E. K. BaidooiD· 3 shared Matthew R. InchaiD· 3 shared Mitchell G. ThompsoniD· 3 shared Christopher J. PetzoldiD· 2 shared Jacob B. RobertsiD· 2 shared Pablo Cruz‐MoralesiD· 2 shared

Activity by Year

2019-2023 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 37 mutual co-author links

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6 shared papersSynthetic Biology

Jay D. KeaslingORCID

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Author profile →

6 papers

Recent·Most cited

Development of Corynebacterium glutamicum as a monoterpene production platform

Bridget A. Luckie, Meera Kashyap, Allison N. Pearson, Yan Chen, Yuzhong Liu, Luis E. Valencia, Alexander Carrillo Romero, Graham A. Hudson, Xavier B. Tao, Yu-Chang Bryan Wu, Christopher J. Petzold, Jay D. Keasling

This paper develops and optimizes a mevalonate-based monoterpene production platform in Corynebacterium glutamicum, achieving high titers of several monoterpenes.

bioRxiv · Oct 31, 2023 · PreprintSynthetic Biology

Foldy: a web application for interactive protein structure analysis

Jacob B. Roberts, Alberto A. Nava, Allison N. Pearson, Matthew R. Incha, Luis E. Valencia, Melody Ma, Abhay Rao, Jay D. Keasling

Foldy provides a cloud-based platform for non-expert scientists to access AI-based structural biology tools like AlphaFold and DiffDock for protein structure prediction and ligand docking.

bioRxiv · May 11, 2023 · PreprintBioinformatics

Engineering Pseudomonas putida KT2440 for chain length tailored free fatty acid and oleochemical production

Luis E. Valencia, Matthew R. Incha, Matthias Schmidt, Allison N. Pearson, Mitchell G. Thompson, Jacob B. Roberts, Marina Mehling, Kevin Yin, Ning Sun, Asun M. Oka, Patrick M. Shih, Lars M. Blank, John M. Gladden, Jay D. Keasling

This paper engineers Pseudomonas putida KT2440 to produce medium- and long-chain free fatty acids and oleochemicals, achieving titers up to 670 mg/L.

Communications Biology · Dec 12, 2022Peer-reviewedSynthetic Biology

A bimodular PKS platform that expands the biological design space

Amin Zargar, Luis E. Valencia, Jessica C Wang, Ravi Lal, Samantha Chang, Miranda Werts, Andrew R. Wong, Amanda C. Hernández, Veronica Teixeira Benites, Edward E. K. Baidoo, Leonard Katz, Jay D. Keasling

The paper engineers bimodular PKS systems to produce unnatural polyketides as bio-based chemicals, demonstrating both successes and challenges in product fidelity.

Metabolic Engineering · Sep 1, 2020Peer-reviewedSynthetic Biology

Identification, characterization, and application of a highly sensitive lactam biosensor from Pseudomonas putida

Mitchell G. Thompson, Allison N. Pearson, Jesus F. Barajas, Pablo Cruz‐Morales, Nima Sedaghatian, Zak Costello, Megan E. Garber, Matthew R. Incha, Luis E. Valencia, Edward E. K. Baidoo, Héctor García Martín, Aindrila Mukhopadhyay, Jay D. Keasling

The paper develops a highly sensitive biosensor for caprolactam and valerolactam from Pseudomonas putida, capable of detecting product titers above background at ~6 g/L.

ACS Synthetic Biology · Dec 16, 2019Peer-reviewedSynthetic Biology

Host engineering for improved valerolactam production in Pseudomonas putida

Mitchell G. Thompson, Luis E. Valencia, Jacquelyn M. Blake-Hedges, Pablo Cruz‐Morales, Alexandria E. Velasquez, Allison N. Pearson, Lauren N. Sermeno, William A. Sharpless, Veronica Teixeira Benites, Yan Chen, Edward E. K. Baidoo, Christopher J. Petzold, Adam M. Deutschbauer, Jay D. Keasling

This study identifies and disrupts genes in Pseudomonas putida that cause unwanted metabolism of valerolactam, increasing its production titer.

bioRxiv · Jun 6, 2019 · PreprintSynthetic Biology