Reversion mutations define minimal BRCA1/2 requirements for therapy resistance
Lorena Magraner-Pardo, William Kerrison, Dragomir B. Krastev, Rachel Alcraft, Hui Xiao, Rachel Brough, Feifei Song, Sheyne S. A. Choi, Aditi Gulati, Manuel Jorge Rodrigues, Sana Intidhar Labidi‐Galy, Éric Pujade-Lauraine, Isabelle Laure Ray-Coquard, Syed Haider, Stephen J. Pettitt, , Christopher J. Lord
The paper identifies BRCA1/2 reversion mutations associated with drug resistance in cancer patients and highlights key domains critical for resistance.
bioRxiv · May 25, 2026 · PreprintCancer Biology