Manuel Jorge Rodrigues

Reversion mutations define minimal BRCA1/2 requirements for therapy resistance

The paper identifies BRCA1/2 reversion mutations associated with drug resistance in cancer patients and highlights key domains critical for resistance.

Human PMS1-dependent non-canonical mismatch repair converges with MBD4 to repair 5-methylcytosine deamination

The paper shows that MBD4 and PMS1-dependent non-canonical MMR work together to repair 5mC deamination, contributing to genome stability.

Exploiting pair correlation function to describe biological tissue structure

This paper introduces PCF-SiM, a framework for quantifying spatial organization in multiplexed imaging data, demonstrating its application in detecting tissue remodeling and spatial interactions in disease models.

Democratizing computational pathology: optimized Whole Slide Image representations for The Cancer Genome Atlas

This paper introduces Giga-SSL, a self-supervised method for learning Whole Slide Image representations from The Cancer Genome Atlas data, improving classification performance and enabling efficient analysis.

Multi-omics comparison of malignant and normal uveal melanocytes reveals novel molecular features of uveal melanoma.

The paper uses multi-omics analysis to compare malignant and normal uveal melanocytes, identifying genomic instability and a BAP1 promoter deletion as key features of uveal melanoma.