Selective activation of IRE-1 safeguards restoration of translation and organismal rejuvenation from adult reproductive diapause
Qiang Fan, Ao Guo, 王淑娟, Wuling Yang, Yong-Hong Yan, Meng‐Qiu Dong
This study shows that refeeding reverses aging-like phenotypes in C. elegans reproductive diapause by selectively activating the IRE-1 branch of UPRER and enhancing protein synthesis and folding.
bioRxiv · Mar 20, 2026 · PreprintCell Biology