Tonic Inhibition is Abolished in GABAA Receptor γ2R43Q Knock-in Mice with Absence Epilepsy and Febrile Seizures.
Kile P. Mangan, Wyatt B. Potter, Aaron B. Nelson, Steven Petrou, Stephen Mark Johnson, Avtar Roopra, Chiara Cirelli, Mathew V. Jones
This study shows that the γ2R43Q GABAA receptor mutation abolishes tonic inhibition in mice, leading to absence epilepsy and febrile seizures.
bioRxiv · Jun 26, 2017 · PreprintNeuroscience