Author

Mathew V. Jones

University of Wisconsin–Madison

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Biology Disciplines

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Neuroscience· 6

Signature Assays, Organisms & Methods

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Organism:mouse· 6 Approach:experimental assay· 5 Assay:electronic health records· 4 Research Focus:cell type annotation· 1 Organism:human· 1 Approach:machine learning (classical)· 1

Frequent Co-Authors

Jesse A. PfammatteriD· 3 shared Rama K. MagantiiD· 3 shared Aaron B. Nelson· 2 shared Chiara CirelliiD· 2 shared Eli P. WallaceiD· 2 shared Kile P. ManganiD· 2 shared Sai Surthi Konduru· 2 shared Steven PetrouiD· 2 shared

Activity by Year

2017-2021 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 13 mutual co-author links

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3 shared papersNeuroscience

Jesse A. PfammatterORCID

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6 papers

Recent·Most cited

Sleep deprivation exacerbates seizures and diminishes GABAergic tonic inhibition

Sai Surthi Konduru, Yu‐Zhen Pan, Eli P. Wallace, Jesse A. Pfammatter, Mathew V. Jones, Rama K. Maganti

The paper shows sleep deprivation worsens seizures and reduces GABAergic tonic inhibition in Kv1.1-/- mice, potentially leading to increased mortality.

Annals of Neurology · Sep 3, 2021Peer-reviewedNeuroscience

Sleep-wake Characteristics in a Mouse Model of Severe Traumatic Brain Injury: Relation to Post-Traumatic Epilepsy.

Sai Surthi Konduru, Eli P. Wallace, Jesse A. Pfammatter, Paulo V. Rodrigues, Mathew V. Jones, Rama K. Maganti

This study examines sleep-wake patterns and epileptiform activity in a mouse model of severe traumatic brain injury (TBI) to determine if sleep features predict post-traumatic epilepsy (PTE).

Epilepsia Open · Dec 24, 2020Peer-reviewedNeuroscience

An automated, machine learning-based detection algorithm for spike-wave discharges (SWDs) in a mouse model of absence epilepsy

Jesse A. Pfammatter, Rama K. Maganti, Mathew V. Jones

This paper develops an SVM-based algorithm to automatically detect and score spike-wave discharges (SWDs) in mice, showing it correlates with human confidence and behavioral state changes.

Epilepsia Open · Jan 14, 2019Peer-reviewedNeuroscience

A CRISPR/Cas9 based strategy to manipulate the Alzheimer’s amyloid pathway

Jichao Sun, Jared Carlson-Stevermer, Utpal Das, Minjie Shen, Marion Delenclos, Amanda M. Snead, Lina Wang, Jonathan Loi, Andrew J. Petersen, Michael E. Stockton, Anita Bhattacharyya, Mathew V. Jones, Andrew A. Sproul, Pamela J. McLean, Xinyu Zhao, , Subhojit Roy

This paper introduces a CRISPR/Cas9 strategy to edit APP and manipulate the amyloid pathway in Alzheimer's disease by reducing β-cleavage and Aβ while increasing α-cleavage.

bioRxiv · Apr 28, 2018 · PreprintNeuroscience

Cortical Tonic Inhibition Regulates the Expression of Spike-and-Wave Discharges Associated with Absence Epilepsy.

Kile P. Mangan, Aaron B. Nelson, Steven Petrou, Chiara Cirelli, Mathew V. Jones

This study shows that cortical tonic inhibition regulates spike-and-wave discharges in absence epilepsy by demonstrating that its blockade induces seizures and its rescue suppresses them in a mouse model.

bioRxiv · Jul 17, 2017 · PreprintNeuroscience

Tonic Inhibition is Abolished in GABAA Receptor γ2R43Q Knock-in Mice with Absence Epilepsy and Febrile Seizures.

Kile P. Mangan, Wyatt B. Potter, Aaron B. Nelson, Steven Petrou, Stephen Mark Johnson, Avtar Roopra, Chiara Cirelli, Mathew V. Jones

This study shows that the γ2R43Q GABAA receptor mutation abolishes tonic inhibition in mice, leading to absence epilepsy and febrile seizures.

bioRxiv · Jun 26, 2017 · PreprintNeuroscience