Chiara Cirelli

This paper introduces SLAP2, a high-speed microscope for measuring submicron synapses and dendritic voltage in behaving mice, revealing nonlinear input-output amplification in neurons.

The paper induces ON/OFF cortical activity in awake mice to mimic sleep functions and shows it reduces sleep need and restores memory consolidation.

This study shows that optogenetic stimulation of cortical neurons can awaken mice from sleep, coma, and anesthesia, indicating cortical sufficiency for arousal.

This paper validates the Perturbational Complexity Index (PCIst) in rats and mice, showing it reliably reflects consciousness states and is influenced by deep cortical layer stimulation.

The paper investigates how sleep and wake affect parallel fiber synapses in Purkinje cells, finding that sleep increases 'naked' spines and alters branched synapse dynamics.

The paper measures stimulus-evoked neurophysiological differentiation in mouse visual cortex neurons across layers and areas, finding greater differentiation in specific layers and areas for unscrambled stimuli.

The paper shows that visual experience during wakefulness affects slow wave activity in the occipital cortex during sleep, with internal visual imagery modulating these changes.

This study shows that somatostatin-positive cortical interneurons drive sleep slow waves by triggering neuronal OFF periods during NREM sleep.

This study shows that cortical tonic inhibition regulates spike-and-wave discharges in absence epilepsy by demonstrating that its blockade induces seizures and its rescue suppresses them in a mouse model.

This study shows that the γ2R43Q GABAA receptor mutation abolishes tonic inhibition in mice, leading to absence epilepsy and febrile seizures.