Rapid selection of HIV envelopes that bind to neutralizing antibody B cell lineage members with functional improbable mutations
O. Swanson, B. Rhodes, A. Wang, X. Shi-Mao, R. Parks, A. Sanzone, M. K. Louder, B. C. Lin, N. Doria-Rose, M. Bonsignori, K. O. Saunders, K. Wiehe, B. F. Haynes, M. L. Azoitei
The paper identifies a minimal set of mutations required for the function of a HIV bnAb and demonstrates in vitro selection of envelope immunogens that can bind to antibodies with these mutations.
bioRxiv · Jan 4, 2021Immunology