Candesartan treatment preserves learning and working memory in female TgF344-AD rats
Christopher G. Sinon, Kathleen Carter, Jing Ma, Pritha Bagchi, Xiancong Zhang, Peter-Jon C. Williams, Eric B. Dammer, Nicholas T. Seyfried, Paul S. García, Roy L. Sutliff, Ihab M. Hajjar
This study shows that candesartan improves learning and working memory in female TgF344-AD rats but not males, through mechanisms involving clusterin and GFAP, independent of blood pressure or amyloid-β changes.
bioRxiv · Jun 14, 2022 · PreprintNeuroscience