Pritha Bagchi

This paper introduces SPARO, a method to simultaneously profile transcriptomes and proteomes of neural cell types, revealing mRNA-protein discordance patterns in astrocytes and neurons.

This study identifies synaptic proteome changes in response to neuroinflammation, revealing mitochondrial and MAPK signaling disruptions in excitatory neurons linked to Alzheimer's disease.

The paper identifies RNA-binding proteins interacting with tau's repeat domain using proximity labeling, showing their enrichment in Alzheimer's and tauopathies.

This study identifies a PERK-B/DLX1 pathway as a novel driver of tau pathology in human PSP and flies, showing DLX1 promotes tau toxicity.

This study uses multiplex proteomics to identify CSF biomarkers of clinical and neuropathological heterogeneity in Lewy body dementia.

The paper identifies Kv1.3 potassium channel interactors in microglia using proximity labeling proteomics, revealing domain-specific interactions with immune signaling proteins during inflammation.

This study investigates the effects of TIMM50 deficiency in human fibroblasts and mouse neurons, finding reduced mitochondrial function and altered potassium channel levels linked to neurological symptoms.

This study investigates the proteomic and phosphoproteomic effects of DUSP4 overexpression in 5xFAD mice, revealing sex-specific molecular mechanisms and validating findings in human AD cohorts.

This study shows that phosphorylation of α-synuclein at Serine-129 is a physiologic trigger for protein interactions and synaptic function, challenging its previous association with pathology.

The paper uses TurboID-NES to profile proteomes of microglial and neuronal cell lines, showing it captures a significant portion of the proteome and responds to LPS treatment.

This study shows that candesartan improves learning and working memory in female TgF344-AD rats but not males, through mechanisms involving clusterin and GFAP, independent of blood pressure or amyloid-β changes.

The paper investigates how N-terminal phosphorylation of FUS affects its protein interactome using proximity labeling and mass spectrometry, revealing distinct interactome changes and functional consequences.

The paper identifies differentially expressed proteins in a mouse model of DOPA-responsive dystonia, revealing shared mechanisms with human dystonic disorders.