Kathleen Carter

Every Cure Knowledge Graph: A Unified Biomedical Knowledge Graph for Drug Repurposing

The paper introduces EC-KG, a unified biomedical knowledge graph for drug repurposing that integrates multiple existing knowledge graphs to enhance coverage and uncover novel mechanistic pathways.

Proteomic Subtyping of Alzheimer's Disease CSF links Blood-Brain Barrier Dysfunction to Reduced levels of Tau and Synaptic Biomarkers

The paper identifies six CSF proteomic subtypes in Alzheimer's disease, linking BBB dysfunction to reduced tau and synaptic biomarkers, particularly in African Americans and men.

Unbiased Classification of the Human Brain Proteome Resolves Distinct Clinical and Pathophysiological Subtypes of Cognitive Impairment

The paper uses proteomic profiling to classify cognitive impairment subtypes in human brain tissues, identifying distinct molecular patterns associated with different clinical outcomes.

Candesartan treatment preserves learning and working memory in female TgF344-AD rats

This study shows that candesartan improves learning and working memory in female TgF344-AD rats but not males, through mechanisms involving clusterin and GFAP, independent of blood pressure or amyloid-β changes.

Large-Scale Deep Multi-Layer Analysis of Alzheimer's Disease Brain Reveals Strong Proteomic Disease-Related Changes Not Observed at the RNA Level

The paper analyzes proteomic data from Alzheimer's disease brains, revealing disease-related changes not seen at the RNA level and identifying potential therapeutic targets.