Ihab M. Hajjar

This paper introduces a method to estimate whole brain PET and fMRI connectomes using spatially constrained independent component analysis and examines their relationship in mild cognitive impairment patients.

This study shows that candesartan improves learning and working memory in female TgF344-AD rats but not males, through mechanisms involving clusterin and GFAP, independent of blood pressure or amyloid-β changes.

The paper identifies brain-linked CSF biomarkers in Alzheimer’s disease using proteomics, revealing altered levels in both brain and CSF across different disease stages.

This study identifies 114 proteins and 5 modules linked to cerebral atherosclerosis in the brain, with 23 proteins and 2 modules also associated with Alzheimer’s dementia, highlighting shared mechanisms involving synaptic signaling and myelination.

The paper identifies protein network modules in Alzheimer's disease brains and cerebrospinal fluid that are associated with energy metabolism and neuroinflammation, suggesting potential biomarkers and therapeutic targets.

The paper identifies metabolites in plasma associated with memory decline in middle-aged individuals using metabolomics.