Probing the CaV1.2 interactome in heart failure identifies a positive modulator of inotropy and lusitropy
Aaron Rodriques, Guoxia Liu, Alexander N. Katchman, Sergey I. Zakharov, Elaine Y. Wan, Marian Kalocsay, Robyn J. Eisert, Gary Andrew Bradshaw, Bi-Xing Chen, Lin Yang, Steven R. Reiken, Xianghai Lai, Ruiping Ji, Najla Saadallah, Veli Kemal Topkara, , Jared Kushner
The paper uses proximity proteomics to study the cardiac dyad in heart failure, identifying Galectin-1 as a positive modulator of cardiac contractility and relaxation.
bioRxiv · May 8, 2025 · PreprintCell Biology