Author

Aaron Rodriques

Columbia University

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Biophysics· 1 Cell Biology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 2 Organism:mouse· 2 Assay:proteomics· 2 Research Focus:cell type annotation· 1 Research Focus:protein design· 1

Frequent Co-Authors

Alexander N. KatchmaniD· 2 shared Bi-Xing Chen· 2 shared Elaine Y. WaniD· 2 shared Jared KushneriD· 2 shared Ruiping JiiD· 2 shared Bence HegyiiD· 1 shared Christopher D. MakinsoniD· 1 shared Donald M. BersiD· 1 shared

Activity by Year

2025-2025 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 41 mutual co-author links

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2 shared papersBiophysics

Alexander N. KatchmanORCID

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2 papers

Recent·Most cited

De novo Design of a Peptide Modulator to Reverse Sodium Channel Dysfunction Linked to Cardiac Arrhythmias and Epilepsy

Ryan W. Mahling, Bence Hegyi, Erin R. Cullen, Timothy M. Cho, Aaron Rodriques, Lucile Fossier, Mohamad Yehya, Lin Yang, Bi-Xing Chen, Alexander N. Katchman, Nourdine Chakouri, Ruiping Ji, Elaine Y. Wan, Jared Kushner, Steven O. Marx, , Manu Ben Johny

This study designs a de novo peptide modulator, ELIXIR, that inhibits pathogenic late sodium current in NaV channels, reversing dysfunction in cardiac arrhythmias and epilepsy models.

Cell · Aug 18, 2025Peer-reviewedBiophysics

Probing the CaV1.2 interactome in heart failure identifies a positive modulator of inotropy and lusitropy

Aaron Rodriques, Guoxia Liu, Alexander N. Katchman, Sergey I. Zakharov, Elaine Y. Wan, Marian Kalocsay, Robyn J. Eisert, Gary Andrew Bradshaw, Bi-Xing Chen, Lin Yang, Steven R. Reiken, Xianghai Lai, Ruiping Ji, Najla Saadallah, Veli Kemal Topkara, , Jared Kushner

The paper uses proximity proteomics to study the cardiac dyad in heart failure, identifying Galectin-1 as a positive modulator of cardiac contractility and relaxation.

bioRxiv · May 8, 2025 · PreprintCell Biology