Long-term Musculoskeletal and Marrow Sparing with Proton FLASH in Juvenile Mice: Implications for Pediatric Osteosarcoma
Zongsheng Hu, U Titt, Yuting Li, Elise Konradsson, Edgardo A Aguilar, Denae W. Neill, Luke Connell, Xiaochun Wang, Henry James Meyer, Mihai Lurascu Gagea, Susan Lynne McGovern, Emil Schüler, Radhe Mohan
This study shows proton FLASH radiotherapy reduces long-term musculoskeletal and marrow toxicities in juvenile mice, suggesting its potential for pediatric osteosarcoma treatment.
bioRxiv · Jan 18, 2026 · PreprintCancer Biology