Emil Schüler

Mitochondrial rewiring supports survival of triple negative breast cancer cells after ionizing radiation

This study shows that TNBC cells surviving ionizing radiation adopt an OPA1-dependent mitochondrial reprogramming that supports their survival and regrowth.

Mitochondrial Responses to Conventional and Ultra-high Dose Rate (FLASH) Radiation

This study investigates how FLASH and conventional radiation affect mitochondrial function in tumor and nontumorigenic cells, finding FLASH preserves mitochondrial integrity in non-tumor cells.

FLASH Radiotherapy Mitigates Radiation-Induced Lymphopenia and Prevents Immunosuppression via Chk1-STAT3 Axis Modulation in a Preclinical Thoracic Irradiation Model

This study shows FLASH radiotherapy reduces lymphocyte apoptosis and prevents immunosuppression by modulating the Chk1-STAT3 pathway in a preclinical model.

Modernizing histopathological analysis: a fully automated workflow for the digital image analysis of the intestinal microcolony survival assay

This paper introduces an automated workflow for analyzing histopathological images of the intestinal microcolony survival assay, achieving accuracy comparable to experts with reduced human error and time.

Long-term Musculoskeletal and Marrow Sparing with Proton FLASH in Juvenile Mice: Implications for Pediatric Osteosarcoma

This study shows proton FLASH radiotherapy reduces long-term musculoskeletal and marrow toxicities in juvenile mice, suggesting its potential for pediatric osteosarcoma treatment.

FLASH radiotherapy spares lymphocytes in tumor-draining lymph nodes and increases infiltration of immune cells in tumors

This study shows FLASH radiotherapy preserves lymphocytes and increases immune cell infiltration in tumors, potentially improving antitumor immune responses.

Discordance in acute gastrointestinal toxicity between synchrotron-based proton and linac-based electron ultra-high dose rate irradiation

This study compares acute gastrointestinal toxicity from synchrotron-based proton and linac-based electron ultra-high dose rate irradiation in mice, finding higher toxicity with proton FLASH compared to conventional and electron treatments.

Redefining FLASH RT: the impact of mean dose rate and dose per pulse in the gastrointestinal tract

This study evaluates how varying radiation beam parameters affect gastrointestinal toxicity and tumor response in mice, finding that high dose per pulse and ultra-high dose rate independently reduce toxicity while maintaining tumor control.