FLASH Radiotherapy Mitigates Radiation-Induced Lymphopenia and Prevents Immunosuppression via Chk1-STAT3 Axis Modulation in a Preclinical Thoracic Irradiation Model
Rong-Hua Tao, Kevin Liu, Edgardo A Aguilar, Min Wang, Sadhna Aggarwal, Denae W. Neill, Brett Velasquez, Sam A. Beddar, Albert C. Koong, Radhe Mohan, Emil Schüler, Steven Hsesheng Lin
This study shows FLASH radiotherapy reduces lymphocyte apoptosis and prevents immunosuppression by modulating the Chk1-STAT3 pathway in a preclinical model.
International Journal of Radiation Oncology*Biology*Physics · Apr 22, 2026Peer-reviewedCancer Biology