Destabilization of Ran C-terminus promotes GTP loading and occurs in multiple Ran cancer mutations
Yuqing Zhang, Jinhan Zhou, Yuping Tan, Qiao Zhou, Aiping Tong, Xiaofei Shen, Da Jia, Xiaodong Sun, Qingxiang Sun
This study shows that destabilizing the C-terminus of Ran promotes GTP loading and is associated with cancer mutations, suggesting a new mechanism for cellular transformation and potential drug targets.
bioRxiv · Apr 20, 2018 · PreprintBiochemistry