Author

Qingxiang Sun

University of Electronic Science and Technology of ChinaORCID 0000-0002-9474-8882Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Microbiology· 2 Biochemistry· 1 Molecular Biology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 4 Research Focus:drug response / drug discovery· 2 Research Focus:benchmarking· 1 Research Focus:cell signaling & trafficking· 1 Research Focus:host-pathogen & immune response· 1 Organism:human· 1 Organism:mouse· 1 Assay:protein structure· 1

Frequent Co-Authors

Da JiaiD· 2 shared Qiaohua Yan· 2 shared Yuping Tan· 2 shared Aiping Tong· 1 shared Bingzhou Huang· 1 shared Cong Li· 1 shared Cuiting FangiD· 1 shared Hang XiongiD· 1 shared

Activity by Year

2018-2026 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 17 mutual co-author links

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2 shared papersMolecular Biology

Da JiaORCID

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4 papers

Recent·Most cited

Discovery of ARQ-501 as a potent PafA inhibitor that elevates KatG levels to potentiate isoniazid in mycobacteria

Cong Li, Bingzhou Huang, Hang Xiong, Qiaohua Yan, Yan Liu, Cuiting Fang, Youfu Luo, Peng Xu, Ting Luo, Qingxiang Sun

The paper identifies ARQ-501 as a PafA inhibitor that increases KatG levels, enhancing isoniazid efficacy against tuberculosis.

bioRxiv · Jun 3, 2026 · PreprintMicrobiology

The Janus face of Selinexor (KPT-330) in bacterial infection: short-term protection versus long-term lethality

Qiaohua Yan, Lu Guo, Qingxiang Sun

This study shows that KPT-330 initially protects against bacterial pneumonia but later causes severe lung injury and death, with antibiotic adjunctive therapy improving survival.

bioRxiv · Oct 16, 2025 · PreprintMicrobiology

Plumbagin and oridonin reveal new CRM1 binding sites and NES-binding groove features

Yuqin Lei, Yuling Li, Yuping Tan, Da Jia, Qingxiang Sun

This study identifies new CRM1 binding sites and structural features of the NES-binding groove using plumbagin and oridonin, revealing potential mechanisms for CRM1 inhibition.

bioRxiv · Aug 5, 2020 · PreprintMolecular Biology

Destabilization of Ran C-terminus promotes GTP loading and occurs in multiple Ran cancer mutations

Yuqing Zhang, Jinhan Zhou, Yuping Tan, Qiao Zhou, Aiping Tong, Xiaofei Shen, Da Jia, Xiaodong Sun, Qingxiang Sun

This study shows that destabilizing the C-terminus of Ran promotes GTP loading and is associated with cancer mutations, suggesting a new mechanism for cellular transformation and potential drug targets.

bioRxiv · Apr 20, 2018 · PreprintBiochemistry