Activation of Vasopressin Receptor 1A by Vasopressin Enhances Myometrial Smooth Muscle Cell Excitability by Inhibiting the Potassium Channel SLO2.1
Juan José Ferreira, Lindsey N. Kent, Ana Gonzalez-Cota, Nikita Peramsetty, Grace C. Whitter, Ethan Li, Sariela Spivak, Xiaofeng J Ma, Sarah K. England, Celia Maria Santi
This study shows AVP activates AVPR1A in myometrial cells, inhibits SLO2.1 potassium channels, depolarizes cells, and enhances Ca²⁺ entry, increasing excitability and contraction.
bioRxiv · Aug 12, 2026 · PreprintPhysiology