Mitochondrial Calcium Uptake Promotes Mitochondrial Activation and Hyperactivated Motility During Human Sperm Capacitation
Pilar Irigoyen, Juan José Ferreira, Adriana Cassina, Shweta Bhagwat, Nikita Peramsetty, Rossana Sapiro, Celia Maria Santi
This study shows that mitochondrial calcium uptake via CatSper and MCU is essential for hyperactivated motility during human sperm capacitation, similar to mouse sperm.
bioRxiv · Oct 2, 2026 · PreprintPhysiology