Cytoplasmic mRNA decay by the anti-viral nuclease RNase L promotes transcriptional repression
Xiaowen Mao, Sherzod A. Tokamov, Felix Pahmeier, Azra Lari, Jinyi Xu, Eva Harris, Britt A. Glaunsinger
This study shows that RNase L, an antiviral nuclease, represses transcription by reducing RNA polymerase II elongation, particularly affecting immune-related genes.
bioRxiv · Jul 8, 2025 · PreprintMolecular Biology