Mutational screening reveals a cluster of residues within the SARS-CoV-2 nsp1 N-terminus that confers RNA-targeting selectivity
Jaresley V. Guillen, Sherzod A. Tokamov, Britt A. Glaunsinger
The paper identifies two clusters of residues in the SARS-CoV-2 nsp1 N-terminal domain that are critical for distinguishing between host and viral mRNA targets and mediating mRNA decay.