Cortical microglia promote noradrenergic signaling to maintain wakefulness
Yue Liang, Wu Shi, Emily M. Dale, Shunyi Zhao, Fangfang Qi, Koichiro Haruwaka, Qixiu Hou, Mengdi Fei, Lauren Harris, Xiaoyang Hua, Long-jun Wu
This study shows that microglia interact with noradrenergic axons in the frontal cortex, enhancing norepinephrine transmission and supporting wakefulness.
bioRxiv · Dec 27, 2025 · PreprintNeuroscience