Koichiro Haruwaka

The paper identifies astrocyte-to-microglia purinergic signaling as a mechanism converting neuronal hypoactivity into synapse-selective microglial regulation of circuit activity.

This study shows that microglial SWELL1 deficiency increases male-specific seizure severity but protects neurons through impaired phagocytosis and reduced neuroactive metabolite release.

This study shows that microglia interact with noradrenergic axons in the frontal cortex, enhancing norepinephrine transmission and supporting wakefulness.

This study identifies satellite microglia in adult mice that modulate inhibitory synapses and neuronal activity by physically shielding inhibitory connections.

The paper shows that impaired microglial phagocytosis due to TREM2 deficiency promotes seizure development in mice and correlates with seizure history in human patients.

This study uses chemogenetic manipulation to show that microglia have both seizure-reducing and seizure-promoting effects in a mouse epilepsy model.

The paper shows that microglial process dynamics shield GABAergic inputs to enhance neuronal activity after anesthesia in mice.