A tumorigenesis threshold for endogenous Myc revealed by dosage-compensation for Myc haploinsufficiency in the absence of p53.
Xiaozhong Bao, Zied Abdullaev, Subhendu Das, Valerie Zgonc, Kris Ylaya, Stefania Pittaluga, Stephen M. Hewitt, John M. Sedivy, Svetlana J. Pack, Susan Mackem, David Levens
This study shows that reducing endogenous Myc levels in p53-deficient mice extends tumor-free survival and that tumors compensate by increasing Myc dosage or expression.
bioRxiv · Jul 28, 2025 · PreprintCancer Biology