Dual-Action Kinase Inhibitors Influence p38α MAP Kinase Dephosphorylation
Emily Jane Stadnicki, Hannes Ludewig, Ramasamy Prem Kumar, Xicong Wang, Youwei Qiao, Dorothee Kern, Niels Bradshaw
The paper identifies dual-action kinase inhibitors that block the active site and enhance p38α dephosphorylation by stabilizing an accessible activation loop conformation.
Proceedings of the National Academy of Sciences · Dec 31, 2024Peer-reviewedBiochemistry