Youwei Qiao

Multiplexed cytokine and antigen mRNA administration generates durable anti-tumor immunity against pancreatic cancer

This study shows that delivering multiple cytokine and antigen mRNAs via nanoparticles can generate strong anti-tumor immunity against pancreatic cancer in mice.

Prime assembly with linear DNA donors enables large genomic insertions

This paper introduces a Prime Assembly method for inserting large DNA fragments into the genome, achieving efficient and precise insertions up to 11 kilobase pairs.

KRAS withdrawal in Cholangiocarcinoma leads to immune infiltration and tumor regression

This study shows that removing KRASG12D in a mouse model of cholangiocarcinoma leads to tumor regression through immune infiltration and activation of CD8+ T cells.

Dual-Action Kinase Inhibitors Influence p38α MAP Kinase Dephosphorylation

The paper identifies dual-action kinase inhibitors that block the active site and enhance p38α dephosphorylation by stabilizing an accessible activation loop conformation.