Hog1/p38 and ZAKα drive Shwachman-Diamond syndrome and provide targets to improve cell growth
Nozomu Kawashima, Nehas Prasad, Frank A. Tedeschi, Hrishikesh Mehta, Noah Saito, Cameron Jones, Xin C. Chen, Anca Manuela Hristodor, Gao Zhou, Joseph M. Luna, Marco Cipolli, Valentino Bezzerri, Seth J. Corey
This study identifies Hog1/p38 and ZAKα as drivers of Shwachman-Diamond syndrome and shows their inhibition can restore cell growth in SDS models.
bioRxiv · Feb 8, 2026 · PreprintCell Biology