Joseph M. Luna

This study identifies Hog1/p38 and ZAKα as drivers of Shwachman-Diamond syndrome and shows their inhibition can restore cell growth in SDS models.

The paper introduces two metrics to quantify RBP binding specificity and variation sensitivity, showing their correspondence in vitro and in cells, and demonstrating emergent competition properties.

The paper identifies PLSCR1 as a host factor restricting SARS-CoV-2 entry, which recent variants have evolved to bypass, through a CRISPR screen and integration of genetic studies.

This study introduces colocalization CLIP to map RNA-protein interactions with subcellular resolution, revealing location-specific binding preferences of HuR in different compartments.