Biosynthetic characterization and combinatorial biocatalysis of the cysteine protease inhibitor E-64
Mengting Liu, Xin Zang, Niko W. Vlahakis, José A. Rodríguez, Masao Ōhashi, Yi Tang
This study characterizes the biosynthesis of E-64, a cysteine protease inhibitor, and demonstrates its biocatalytic potential for generating potent analogs.
Nature Chemical Biology · May 9, 2025Peer-reviewedBiochemistry