Author

Niko W. Vlahakis

University of California, Los AngelesORCID 0000-0002-5092-0265Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Biochemistry· 1 Biophysics· 1

Signature Assays, Organisms & Methods

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Research Focus:drug response / drug discovery· 2 Approach:experimental assay· 2 Organism:fungi (other)· 1 Research Focus:protein structure prediction· 1 Assay:structural biology· 1

Frequent Co-Authors

José A. RodrígueziD· 2 shared Mengting LiuiD· 2 shared Yi TangiD· 2 shared Cameron W. FlowersiD· 1 shared Catherine Keyser· 1 shared Daniele de SanctisiD· 1 shared Hosea M. NelsoniD· 1 shared Jacob A. SummersiD· 1 shared

Activity by Year

2025-2025 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 45 mutual co-author links

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2 shared papersBiochemistry

José A. RodríguezORCID

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2 papers

Recent·Most cited

Biosynthetic characterization and combinatorial biocatalysis of the cysteine protease inhibitor E-64

Mengting Liu, Xin Zang, Niko W. Vlahakis, José A. Rodríguez, Masao Ōhashi, Yi Tang

This study characterizes the biosynthesis of E-64, a cysteine protease inhibitor, and demonstrates its biocatalytic potential for generating potent analogs.

Nature Chemical Biology · May 9, 2025Peer-reviewedBiochemistry

Combining MicroED and native mass spectrometry for structural discovery of enzyme-biosynthetic inhibitor complexes

Niko W. Vlahakis, Cameron W. Flowers, Mengting Liu, Matthew P. Agdanowski, Samuel E. Johnson, Jacob A. Summers, Catherine Keyser, Phoebe Russell, Samuel L. Rose, Julien Orlans, Nima Adhami, Yu Chen, Michael R. Sawaya, Shibom Basu, Daniele de Sanctis, , José A. Rodríguez

This paper combines MicroED and native mass spectrometry to determine structures of enzyme-inhibitor complexes and identify high-affinity ligands from crude samples.

bioRxiv · Feb 20, 2025 · PreprintBiophysics