Yi Tang

The paper identifies two fungal P450 enzymes that catalyze oxidative demethylation of prenyl groups to form allenes and alkynes in natural products.

This paper identifies a fungal natural product, MDD, as a novel cellulose biosynthesis inhibitor that targets CESA1 and disrupts cellulose synthase complexes, enabling the development of multi-drug resistant crop varieties.

This study identifies a novel antifungal compound targeting ALS, validated through genome mining, biochemical assays, and a mouse model of invasive aspergillosis.

This study characterizes the biosynthesis of E-64, a cysteine protease inhibitor, and demonstrates its biocatalytic potential for generating potent analogs.

This paper combines MicroED and native mass spectrometry to determine structures of enzyme-inhibitor complexes and identify high-affinity ligands from crude samples.

The paper identifies the biosynthetic pathway for 3-NPA in Aspergillus oryzae using genome mining, genetic inactivation, and biochemical analysis.

A yeast-based refactoring platform (HEx) with new inducible promoters, an engineered host strain, and homology-based assembly expressed 41 cryptic fungal gene clusters; 22 yielded non-native compounds.