Combinatorial base editing couples disease correction with lineage amplification in hematopoietic stem and progenitor cells
Kun Jia, Eric Soupène, Roshani Sinha, Benjamin J. Lesch, Michael A. Pendergast, Rachel Choi, Xinyi Zhang, Elisabetta Manuela Foppiani, Zachary Kostamo, Simon N. Chu, Devesh Sharma, Xinjie Yu, Marco Cordero, Mark C. Walters, Tippi C. MacKenzie, , M. Kyle Cromer
This paper develops a combinatorial base editing strategy to enhance erythroid lineage amplification and disease correction in hematopoietic stem and progenitor cells.
bioRxiv · Apr 14, 2026 · PreprintCell Biology