Bioorthogonal labeling and enrichment of histone monoaminylation reveal its accumulation and regulatory function in cancer cell chromatin
Nan Zhang, Jinghua Wu, Farzana Hossain, Haidong Peng, Huapeng Li, Connor Gibson, Min Chen, Huan Zhang, Shuaixin Gao, Xinru Zheng, Yong‐Dong Wang, Jiangjiang Zhu, Jing Jing Wang, Ian S. Maze, Qingfei Zheng
This study develops chemical probes to label and enrich histone monoaminylation, revealing its enrichment in cancer tissues and its role in chromatin architecture regulation.
Journal of the American Chemical Society · Jun 7, 2024Peer-reviewedBiochemistry