Ian S. Maze

This study identifies KMT2E as a reader of H3K4me3Q5ser, showing its role in regulating chromatin dynamics and neurodevelopmental gene expression in ODLURO syndrome.

This study shows early-life stress alters chromatin modifications in the VTA, increasing stress sensitivity through changes in histone dynamics and Setd7 activity.

This study shows that deleting transglutaminase 2 improves metabolic support from astrocytes and reduces pathology after repetitive mild traumatic brain injury.

This study identifies QR2 as a reader of H3Q5ser, showing its role in human neuron development through transcriptional and electrophysiological effects.

The paper shows that histone serotonylation, induced by mesoderm stiffening through Tgm2 nuclear translocation, is essential for initiating collective neural crest cell migration in vivo.

The paper identifies ZBTB7A as a key regulator of MDD-specific chromatin signatures and astrocyte-mediated stress vulnerability in the orbitofrontal cortex.

This study identifies dopamine-dependent transcriptional changes in the dorsal hippocampal formation during pregnancy and postpartum, showing how dopamine modulates neural plasticity and behavior.

This study shows that cocaine exposure increases calreticulin in the ventral hippocampus via ΔFosB, reducing excitability in the vHPC-NAc circuit and promoting cocaine seeking and reward.

The paper investigates how stress-induced plasticity in the amygdala and ventral hippocampus differentially supports non-associative defensive behaviors.

The paper identifies dopaminylated proteins in the brain, including γCaMKII, and shows its role in synaptic-to-nuclear signaling and memory formation.

This study develops chemical probes to label and enrich histone monoaminylation, revealing its enrichment in cancer tissues and its role in chromatin architecture regulation.

The paper shows that serotonin transporter-dependent H3 serotonylation in placenta regulates neurodevelopmental gene networks in embryos.

The paper investigates how serotonin modifies histone H3K4me3Q5ser dynamics in the dorsal raphe nucleus under stress and antidepressant exposure, showing its role in gene expression and behavior.

The paper shows neuronal activity induces Slc22a3 in astrocytes, which affects histone serotonylation and GABA release, leading to olfactory deficits.

A single enzyme, TGM2, bidirectionally controls H3 monoaminylation dynamics, which, in turn, facilitate neural rhythmicity.

This study shows that H3Q5dop in VTA contributes to heroin-induced transcriptional plasticity and relapse vulnerability during abstinence.

The paper identifies extracellular histones as new inhibitors of CNS axonal regeneration, showing they induce growth cone collapse and can be reversed by activated protein C.

The paper identifies Zfp189 as a key driver of a transcriptional network promoting stress resilience in prefrontal cortex neurons through CREB regulation.