Author

Jinghua Wu

The Ohio State University Comprehensive Cancer Center – Arthur G. James Cancer Hospital and Richard J. Solove Research InstituteORCID 0000-0001-6198-2763Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Biochemistry· 4

Signature Assays, Organisms & Methods

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Approach:experimental assay· 3 Organism:human· 3 Assay:proteomics· 2 Research Focus:cell type annotation· 1 Assay:ChIP-seq· 1 Research Focus:chromatin & epigenetic regulation· 1 Approach:deep learning· 1 Research Focus:protein folding & dynamics· 1

Frequent Co-Authors

Qingfei ZhengiD· 4 shared Connor Gibson· 3 shared Haidong Peng· 3 shared Huapeng LiiD· 3 shared Jiangjiang ZhuiD· 3 shared Shuaixin GaoiD· 3 shared Sophia WuiD· 2 shared Adam R. Lovato· 1 shared

Activity by Year

2024-2025 · peak 3/yr

Co-Author Collaboration Network

10 top collaborators · 30 mutual co-author links

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4 shared papersBiochemistry

Qingfei ZhengORCID

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4 papers

Recent·Most cited

BiochemistryRSC Chemical BiologyPeer-reviewedJan 1, 2025

Regioselective Rapid Ene-type Reaction (RRER) Enables Bioconjugation of Histone Serotonylation

Jinghua Wu, Huapeng Li, Adam R. Lovato…·Qingfei Zheng

This study introduces a pH-controlled regioselective rapid ene-type reaction (RRER) for selectively modifying histone H3Q5 serotonylation and measuring its levels in cells and tissues.

3 citations

experimental assay

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BiochemistryJournal of Proteome ResearchPeer-reviewedAug 29, 2024

pH-Controlled chemoselective rapid azo-coupling reaction (CRACR) enables global profiling of serotonylation proteome in cancer cells

Nan Zhang, Jinghua Wu, Shuaixin Gao…·Qingfei Zheng

The paper develops a chemical proteomic method to globally profile serotonylation in cancer cells, identifying over 1,000 serotonylated proteins and their modification sites.

17 citations

humanproteomics

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BiochemistryJournal of the American Chemical SocietyPeer-reviewedJun 7, 2024

Bioorthogonal labeling and enrichment of histone monoaminylation reveal its accumulation and regulatory function in cancer cell chromatin

Nan Zhang, Jinghua Wu, Farzana Hossain…·Qingfei Zheng

This study develops chemical probes to label and enrich histone monoaminylation, revealing its enrichment in cancer tissues and its role in chromatin architecture regulation.

29 citations

humanChIP-seq

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BiochemistryJournal of Proteome ResearchPeer-reviewedJun 5, 2024

Chemical proteomic profiling of protein dopaminylation in colorectal cancer cells

Nan Zhang, Shuaixin Gao, Haidong Peng…·Qingfei Zheng

The paper identifies 425 dopaminylated proteins in colorectal cancer cells using a chemical probe, revealing their involvement in nucleic acid metabolism and transcription, and suggests targeting protein dopaminylation as a potential anti-cancer strategy.

18 citations

humanproteomics

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