An engineered IdeS variant with enhanced activity and performance for IgG degradation
Keyi Zhang, Wenhao Ma, Zhijie Wu, Zipei Ren, Congcong Chen, Yan Xia, Dan He, Z-F Yu, Hongze Niu, Jing Qin, Pan Gao, WY Yang, Yangguang Dai, Xiu Li, Zheyue Dong, , XC Wu
This paper engineers an improved IgG-degrading enzyme, IdeSM33, showing enhanced activity and IgG depletion in vivo, with therapeutic potential for autoimmune diseases and gene therapy.
bioRxiv · Jul 1, 2026 · PreprintBioengineering