This paper introduces gANCHOR, a T-cell foundation model that predicts CAR T-cell immunotherapy response by integrating gene-level structure with clinical outcomes, achieving high F1 score and biological insights.

bioRxiv · Jul 16, 2026 · PreprintBioinformatics

An engineered IdeS variant with enhanced activity and performance for IgG degradation

Keyi Zhang, Wenhao Ma, Zhijie Wu, Zipei Ren, Congcong Chen, Yan Xia, Dan He, Z-F Yu, Hongze Niu, Jing Qin, Pan Gao, WY Yang, Yangguang Dai, Xiu Li, Zheyue Dong, , XC Wu

This paper engineers an improved IgG-degrading enzyme, IdeSM33, showing enhanced activity and IgG depletion in vivo, with therapeutic potential for autoimmune diseases and gene therapy.

bioRxiv · Jul 1, 2026 · PreprintBioengineering

Foxp4+ Mandibular Skeletal Stem Cells Orchestrate Bone/Tooth Development and Regeneration

L J Zhang, Dandan Cao, X Li, Hongqiang Yu, Jianfang Wang, Qiaoling Zhu, Xinyi Zhang, Chen Chen, Gongchen Li, Xinyu Xu, Xiaoqiao Xu, Dike Tao, Xuyan Gong, Pingping Niu, XC Wu, , Yao Sun

This study identifies Foxp4+ mandibular skeletal stem cells (mdSSCs) that drive bone/tooth development and regeneration, showing their therapeutic potential in regenerating mandibular structures.

bioRxiv · May 1, 2026 · PreprintCell Biology