High-resolution reconstruction of cell-type specific transcriptional regulatory processes from bulk sequencing samples
Yao Li, Sagar R Shah, Abdullah Ozer, Yutong Zhu, Xiuqi Pan, Tianyu Xia, Junke Zhang, Alden King-Yung Leung, Meihan Wei, John T. Lis, Haiyuan Yu
This paper introduces DeepDETAILS, a method to reconstruct cell-type-specific genomic signals from bulk data, outperforming traditional methods and providing insights into disease mechanisms.
Nature Biotechnology · Jul 13, 2026Peer-reviewedBioinformatics