Junke Zhang

Simultaneous measurement of intrinsic promoter and enhancer potential reveals principles of functional duality and regulatory reciprocity

The paper develops a dual reporter assay to measure promoter and enhancer potential, finding that they share regulatory logic and can function reciprocally.

A multiscale functional map of somatic mutations in cancer integrating protein structure and network topology

This paper introduces NetFlow3D, a framework that integrates protein structure and interaction networks to identify significant mutation clusters and modules in cancer, revealing biological processes not found by traditional methods.

A multifaceted role of progranulin in regulating amyloid-beta dynamics and responses

This study shows that PGRN deficiency affects amyloid-beta levels and microglial activation in a sex- and age-dependent manner, influencing lysosomal activity and inflammation in Alzheimer's disease.