Lymphatics unload VEGFR3 in response to the alteration of VEGFR2-mediated transcriptional programs
T J Li, Xudong Cao, Fei Zhou, X G Li, W X, Xiuyan Zhang, H Zhong, Beibei Xu, Man Chu, Xiwen Jia, Kai Ding, Xin Shen, Yahui Liu, Yun Zhao, Zhen Zhang, , Yulong He
This study shows that VEGFR2 is essential for maintaining lymphatic endothelial identity and its loss alters transcriptional programs, reducing VEGFR3-mediated lymphangiogenesis.
Angiogenesis · Jul 26, 2026Peer-reviewedDevelopmental Biology