Author

Lena Claesson

Uppsala UniversityORCID 0000-0003-4275-2000Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Signature Assays, Organisms & Methods

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Organism:mouse· 3 Approach:experimental assay· 2 Assay:bulk RNA-seq· 1 Research Focus:differential expression· 1 Research Focus:gene regulatory network inference· 1 Assay:imaging· 1 Research Focus:spatial domain detection· 1 Approach:statistical model· 1

Frequent Co-Authors

Abelardo López‐RivasiD· 1 shared Aida Freire-Valls· 1 shared Ana M. FigueiredoiD· 1 shared Ana Martins RussoiD· 1 shared Andreia PenaiD· 1 shared Beibei XuiD· 1 shared Boris StrilićiD· 1 shared Carmen Ruiz de AlmodóvariD· 1 shared

Activity by Year

2019-2026 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 16 mutual co-author links

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1 shared paperDevelopmental Biology

Abelardo López‐RivasORCID

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Author profile →

3 papers

Recent·Most cited

Lymphatics unload VEGFR3 in response to the alteration of VEGFR2-mediated transcriptional programs

T J Li, Xudong Cao, Fei Zhou, X G Li, W X, Xiuyan Zhang, H Zhong, Beibei Xu, Man Chu, Xiwen Jia, Kai Ding, Xin Shen, Yahui Liu, Yun Zhao, Zhen Zhang, , Yulong He

This study shows that VEGFR2 is essential for maintaining lymphatic endothelial identity and its loss alters transcriptional programs, reducing VEGFR3-mediated lymphangiogenesis.

Angiogenesis · Jul 26, 2026Peer-reviewedDevelopmental Biology

Mouse retinal cell behaviour in space and time using light sheet fluorescence microscopy

Claudia Prahst, Parham Ashrafzadeh, Thomas Mead, Ana M. Figueiredo, Karen Chang, Douglas S. Richardson, Lakshmi Venkaraman, Mark Richards, Ana Martins Russo, Kyle Harrington, Marie Ouarné, Andreia Pena, Dong Feng Chen, Lena Claesson, Kin‐Sang Cho, , Katie Bentley

This paper demonstrates the feasibility of 3D/4D light-sheet fluorescence microscopy for imaging mouse retinal pathology, revealing new features in the OIR model and highlighting distorted morphology from flat-mounting.

eLife · Feb 19, 2020Peer-reviewedDevelopmental Biology

Caspase-8 Modulates Angiogenesis By Regulating A Cell Death Independent Pathway In Endothelial Cells

Nathalie Tisch, Aida Freire-Valls, Rosario Yerbes, Isidora Paredes, Silvia La Porta, Xiaohong Wang, Rosa Martín‐Pérez, Laura Castro, Wendy Wei-Lynn Wong, Leigh Coultas, Boris Strilić, Hermann‐Josef Gröne, Thomas Hielscher, Carolin Mogler, Ralf H. Adams, , Carmen Ruiz de Almodóvar

This study shows that Caspase-8 promotes angiogenesis in endothelial cells through a cell death-independent mechanism involving p38 MAPK activation and VE-cadherin destabilization.

bioRxiv · Jul 22, 2019 · PreprintDevelopmental Biology