Dynamic S-acylation of GSDMA regulates pyroptosis
Zhipeng Tao, Ritesh Thakare, Melyssa Cheung, Jianan Zhang, Xin Chen, Xiaodi Hu, Brian G. Pierce, Xu Wu, Junhao Mao
This study shows that GSDMA undergoes S-acylation, which promotes pyroptosis by enhancing membrane anchoring and oligomerization, distinct from GSDMD's palmitoylation mechanism.
ACS Chemical Biology · Apr 13, 2026Peer-reviewedBiochemistry