Survivin inhibition induces PD-L1 expression through cGAS stabilization and attenuates antitumor immunity
Yun Liu, Hui Shen, Jinzhou Li, Weiqiang Yu, Tingting Yin, Xiaodong Yuan, Wenwu Luo, Yan Li, Xue Peng, Aoxing Cheng, Jing Guo, Zhenye Yang, Fazhi Yu
This study shows that Survivin inhibition increases PD-L1 expression via cGAS stabilization, leading to immune evasion and reduced antitumor immunity.
bioRxiv · May 1, 2026 · PreprintCancer Biology