A novel vimentin variant from tumor-associated macrophages directs cancer metastasis by engaging IGF-1R
Chenglin Miao, Xuedi Gao, Jingjing Mao, Wentong Wang, Zhifang Li, Zhiqin Chen, Zeyu Wen, Yuhan Huang, Xinyi Huang, Xin Liang, Xin Liu, Gaofeng Fan, Chenxi Tian, Suwen Zhao, Chengyuan Wang, , Yaming Jiu
This study identifies a novel vimentin variant secreted by tumor-associated macrophages that promotes cancer metastasis by activating IGF-1R and increasing integrin expression.
bioRxiv · Feb 27, 2025 · PreprintCell Biology