Chengyuan Wang

This paper characterizes OLD, an abortive immunity protein, revealing its structure and activation mechanism in response to phage replication and DNA defects in RecBCD-compromised cells.

The paper reports structures of long-range coupled transcription-translation complexes (TTC-LC) in E. coli, showing how they differ from TTC-B and their roles in transcription-translation coupling.

This paper introduces DEMO-EMReF, a Transformer-based framework for refining cryo-EM density maps, improving resolution and atomic model accuracy.

This study identifies a novel vimentin variant secreted by tumor-associated macrophages that promotes cancer metastasis by activating IGF-1R and increasing integrin expression.

The paper reports the structure of the archaeal FttA pre-termination complex using cryo-EM, revealing its mechanism of action and functional homology with bacterial and eukaryotic systems.

Cryo-EM reveals the structural basis of transcription-translation coupling by RfaH.

The paper reports cryo-EM structures of transcription-translation complexes (TTCs) at different stages of the translation cycle in E. coli, revealing structural changes and their functional implications.

The paper reports cryo-EM structures of functional Rho pre-termination complexes in Escherichia coli, explaining their mechanism and resolving decades of research.

The paper identifies CTL0286 as the chlamydial RNA polymerase omega subunit and shows it is conserved across obligate intracellular bacteria.

The paper uses cryo-EM to define structural states of transcription-translation complexes in bacteria that mediate NusG- and NusA-dependent coupling.