Cell-free DNA fragmentomic characteristics in transposon elements inform molecular regulators and enhance cancer diagnosis
Fanglei Gong, Yuqi Pan, Huizhen Lin, Yunyun An, Mengqi Yang, Xiaoyi Liu, Yunxia Bai, Wanqiu Wang, Zhenyu Zhang, Bianbian Tang, Kun Zhang, Xin Zhao, Yu Fen Zhao, Changzheng Du, Xuetong Shen, Kun Sun
This study identifies cfDNA fragmentomic features in transposon elements as biomarkers for cancer diagnosis, showing improved performance over genome-wide measurements.
bioRxiv · Jul 10, 2025 · PreprintCancer Biology