This study identifies cancer-like fragmentomic traits in somatic variants of cfDNA, enabling cancer diagnosis through integrative genomic and fragmentomic analysis using AI models.

Advanced Science · Jan 22, 2026Peer-reviewedCancer Biology

Cell-free DNA fragmentomic characteristics in transposon elements inform molecular regulators and enhance cancer diagnosis

Fanglei Gong, Yuqi Pan, Huizhen Lin, Yunyun An, Mengqi Yang, Xiaoyi Liu, Yunxia Bai, Wanqiu Wang, Zhenyu Zhang, Bianbian Tang, Kun Zhang, Xin Zhao, Yu Fen Zhao, Changzheng Du, Xuetong Shen, Kun Sun

This study identifies cfDNA fragmentomic features in transposon elements as biomarkers for cancer diagnosis, showing improved performance over genome-wide measurements.

bioRxiv · Jul 10, 2025 · PreprintCancer Biology

Presence of Hepatitis B virus infection in colon cancer

Lishi Li, Wenjing Gong, Yunyun An, Hua Tong, Mengqi Yang, Wanqiu Wang, Ma Li, Shiliang Tu, Yang Liu, yunfeng duan, Kun Sun

This study investigates HBV infection in colon cancer patients, finding HBsAg in colonic cells and immune cells, with higher infection rates in tumors.

bioRxiv · Mar 30, 2025 · PreprintCancer Biology

Proteasome inhibition induces DNA methylation alteration by attenuating the synthesis of DNA methyltransferase 1 and 3B in colorectal cancer

Wenwen Zhou, Yuling Sheng, Dingxue Hu, Yunyun An, Mengqi Yang, Wanqiu Wang, Shiva Basnet, Jingyu Yan, Shuxia Zhang, Qi Liu, Yunze Li, Yi Liang Tan, Jing Gao, Kun Sun, Changzheng Du

This study shows proteasome inhibition alters DNA methylation in colorectal cancer by reducing DNMT1 and DNMT3B synthesis via AKT/mTOR inactivation.

Scientific Reports · Mar 12, 2025Peer-reviewedCancer Biology

Candida albicans drives colorectal cancer progression by inducing hypoxia signaling

Wanqiu Wang, Mengqi Yang, Fanglei Gong, Zhenyu Zhang, Yanping Ma, Haihuang Li, Yu Zhao, Changzheng Du, Ningning Li, Guiwei He, Kun Sun

This study shows Candida albicans promotes colorectal cancer by activating hypoxia signaling through EGFR/TLR2 pathways.

bioRxiv · Dec 25, 2024 · PreprintCancer Biology

Plasma cell-free DNA promise disease monitoring and tissue injury assessment of COVID-19

Yanqun Wang, Jie Li, Lu Zhang, Hai‐Xi Sun, Zhaoyong Zhang, Jinjin Xu, Yonghao Xu, Yu Lin, Airu Zhu, Yuxue Luo, Haibo Zhou, Yan Ling Wu, Shanwen Lin, Yuzhe Sun, Fei Xiao, , Xin Jin

This study analyzes cell-free DNA in COVID-19 patients to show its potential for disease monitoring and tissue injury assessment.

Genome Research · Feb 1, 2022Peer-reviewedGenetic & Genomic Medicine

Atlas of ACE2 gene expression in mammals reveals novel insights in transmission of SARS-Cov-2

Kun Sun, Liuqi Gu, Li Ma, Yunfeng Duan

The paper constructs an ACE2 expression atlas across mammals to identify potential hosts and transmission pathways for SARS-CoV-2.

Heliyon · Dec 25, 2020Peer-reviewedGenomics